Clinical Biochemicals > Biochemical reagents
Biochemical reagents-2
Reference Range
Comments
7-20 mg/dL
The blood urea nitrogen (BUN) test is a somewhat routine test used primarily to evaluate renal (kidney) function. The test is often performed on patients with many different diseases.


•Congestive heart failure
•excessive protein catabolism (for example, starvation)
•excessive protein ingestion
•gastrointestinal bleeding
•hypovolemia (for example, burns and dehydration)
•myocardial infarction
•renal disease (for example, glomerulonephritis, pyelonphritis, and acute tubular necrosis) or failure
• urinary tract obstruction (for example, tumor, stones, and prostatic hypertrophy)

•liver failure
•low protein diet
•malnutrition
•over hydration

Reference Range
Comments
125-240 mg/dL
This test is often performed to evaluate risks for heart disease.
Evaluated cholesterol levels may be caused by:
Biliary cirrhosis, familial hyperlipidemias, high-cholesterol diet, hypothyroidism, nephritic syndrome, uncontrolled diabetes .


•hyperthyroidism
• liver disease
•malabsorption (inadequate absorption of nutrients from the intestinal tract)
•malnutrition
•pernicious anemia
•sepsis

Reference Range
Comments
M 30-70 mg/dL,
F 31-79 mg/dL
This test is used in an evaluation of coronary risk factors.
An HDL 60 mg/ml or above helps protect against heart disease .


•Increased risk of atherosclerotic heart disease.
 

Reference Range
Comments
<160 mg/dl

Optimal: < 100 mg/dl
Near Optimal: 100-129 mg/dl
Borderline High: 130-159 mg/dl
High: 160-189 mg/dl
Very High: > 190 mg/dl

This test is usually performed as part of an evaluation of coronary risk factors.
LDL cholesterol level is a better indicator of your risk for a heart attack and stroke than total cholesterol.


•Increased risk of atherosclerotic heart disease
•Familial hyperlipoproteinemia
 

Reference Range
Comments
20-200 mg/dl

NormalL < 150 mg/dl
Borderline High: 150-199 mg/dl
High: 200-499 mg/dl
Very High: > 500 mg/dl

Triglycerides are often measured as a reflection of fat (lipid) ingestion and metabolis, or as part of an evaluation of coronary risk factors.


• Cirrhosis
•Familial hyperlipoproteinemia (rare)
•Hypothyroidism
•Low protein in diet and high carbohydrates
•Poorly controlled diabetes
•Nephrotic syndrome
•Pancreatitis

•Malabsorption syndrome (inadequate absorption of nutrients in the intestinal tract)
•Malnutrition
•Hyperthyroidism
•Low fat diet

Reference Range
Comments
M 27-168 U/L,
F 24-120 U/L
When a muscle is damaged, CPK leaks into the bloodstream.


•Heart attack
•myocarditis (inflammation of the heart muscle)
•central nervous system trauma or stroke
•convulsions
•delirium tremens
•dermatomyositis or polymyositis
•electric shock
•muscular dystrophies
•pulmonary infarction (tissue death)

Reference Range
Comments
Total : M 27-168,
F 24-120 U/L
MM >94-96%,
MB <4-6%,
BB 0%
CPK isoenzymes are performed when the total CPK level is elevated and help differentiate the source of the damaged tissue.


•crush injuries of skeletal muscleo or muscular dystrophy
•multiple intramuscular injections
•myositis (skeletal muscle inflammation)
•post-electromyography (a test of nerve and muscle function)
•recent seizures or recent surgery
•rhabdomyolysis (skeletal muscle damage due to drugs or prolonged immobilization)
•strenuous exercise

•heart attack or open heart surgery
•myocarditis (inflammation of the heart muscle mostly due to viruses)
•electrical injuries
•trauma to the heart (for instance, from a car accident)
•heart defibrillation (purposeful shocking of the heart by medical personnel)

•brain cancer
•brain injury (due to trauma, stroke or bleeding in the brain)
•electroconvulsive therapy
•pulmonary infarction
•seizure
 

Reference Range
Comments
M 2.5-7.2 mg/dl,
F 1.8-6.2 mg/dl
This test is performed to detect elevated uric acid levels. Increased levels of uric acid can cause gout. An overproduction of uric acid occurs when there is excessive breakdown of cells, which contain purines, or the inability of the kidneys to excrete uric acid.


•acidosis
•alcobolism
•diabetes
•gout
•hypoparathyridism
•lead poisoning
•leukemia
•niphrolithiasis
•polycythemia vera
•renal failure
•toxemia of pregnancy
•purine-rich diet
•severe exercise

•Fanconi's syndrome
•Wilson's disease
•SIADH
•low purine diet

Reference Range
Comments
M 0.7-1.5 mg/dl,
F 0.5-1.2 mg/dl
The test is performed to evaluate kidney function. If kidney function is abnormal, creatinine levels will increase in the blood, due to decreased excretion of creatinine in the urine. Creatinine levels also vary according to a persons size and muscle mass.


•Acute tubular necrosis
•Dehydration
•Diabetic nephropathy
•Eclampsia
•Glomerulonephritis
•Muscular dystrophy
•Pre-eclampsia
•Pyelonephritis
•Reduced renal blood flow (shock, congestive heart failure)
•Renal failure
•Rhabdomyolysis
•Urinary tract obstruction

•Muscular dystrophy (late stage)
•Myasthenia gravis

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